尿微量蛋白检测在DN早期诊断的意义

Diagnostic Significance of Detection of Micro-Amount of Urinary Proteins for Patients with early Diabetic Nephropathy

目的:探讨尿微量蛋白测定在糖尿病肾病(DN)早期诊断的意义.方法:用RIA法分别测定65例早期DN患者(以尿白蛋白排泄率持续20～200μg/min为标准诊断.患者组A、40例无DN的糖尿病患者(患者组B)和52例正常健康人(对照组)晨尿中的微量白蛋白(Micro-albumin,mAlb)、转铁蛋白(transferrin,TRF)、β2-微球蛋白(β2-microglobulin,β2-m)和α1-微球蛋白(α1-microglobulin,α1-m)的水平.结果:患者组A与患者组B及对照组比较,各项检测指标均明显增高(P＜0.05,其中TRFP＜0.01),有显著性差异.而患者组B与对照组比较,各项检测指标均无明显变化(P＞0.05).结论:DN早期肾损害与尿微量蛋白密切相关,尿mAlb、TRF、β2-m和α1-m是反映早期DN的敏感指标.

Objective To investigate the diagnostic significance of detection of micro-amount of urinary proteins in patients with early diabetic nephropathy. Methods Urinary micro-amount of albumin (MA) and tranferrithin (TRF), β 2-microglobulin (β 2-m)、α 1-microglobulin (α 1-m) contents were measared with RIA in: ①Group A, 65 type Ⅱ diabetes mellitus (DM-2) patients with early DN (urinary albumin excretion rate=20~200μg/min) ② Group B, 40 DM-2 patients without DN and ③ 52 controls. Results Urinary contents of all these four kinds of protein in Group A patients were significantly higher than those in Group B patients and controls (P<0.05; for TRF, P<0.01). However, contents in Group B patients were not much different from those in controls. Conclusion Urinary MA, TRF, β 2-m and α 1-m were sensitive markers for detection of early DN.