胸水多项肿瘤标志物检测的临床价值

Clinical Values of Detection of Multiple Tumor Markers in Pleural Fluid for Diagnosis Malignancy

目的:通过对胸水中多项肿瘤标志物的联合检测来鉴别癌性、结核性胸水,以提高癌性胸水诊断的阳性率。方法:采用多肿瘤标志物蛋白芯片诊断系统,检测60例癌性胸水和30例结核性胸水中的12种常见肿瘤标志物。结果:癌性胸水组中CEA、NSE、SF、CA125四项肿瘤标志物均值数、阳性率均显著高于结核性胸水组。四种指标联检对癌性胸水的诊断阳性率可达96 7%。结论:胸水CEA、NSE、SF、CA125联检对鉴别良恶性胸水有重要价值,且可显著提高癌性胸水的阳性诊断率。

Objective To improve the diagnostic accuracy for the differentiation of malignant from tuberculous pleural effusion with determination of multiple tumor markers in pleural fluid. Methods With a multiple tumor markers combined protein chip diagnostic system, contents of twelve common tumor markers were detected in the chest fluid from 60 patients with malignant pleural effusion and 30 patients with tuberculous pleural effusion. Results For pulmonary carcinoma related pleural effusion, the contents of four commontumor markers (CEA,NSE,SF,CA125) in chest fluid were significantly higher those in tuberculous related chest fluid. The diagnostic positive rate of combined test of these four marker for malignancy could be as high as 96.7%. Conclusion Combined determination of chest fluid CEA,NSE,SF,CA125 contents was very sensitive and accurate for differentiation of malignant from tuberculous pleural effusion.