普罗布考对老年冠心病抗炎症及抗氧化作用的初步研究

The anti-inflammation and anti-oxidation effect of probucol on the old patients with coronary heart disease

目的评价普罗布考对老年冠心病患者抗炎症及抗氧化作用的疗效。方法随机将63例老年冠心病患者分为两组,其中治疗组(35例),服用普罗布考0.5g,2次/d,疗程均为12周;对照组(28例),未服用任何调脂药物及抗氧化剂。分别于服药前后检测血浆高敏感C反应蛋白(hs-CRP)及氧化低密度脂蛋白(ox-LDL)水平。结果①普罗布考组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)水平以及hs-CRP及ox-LDL水平显著下降;②对照组TC、LDL-C、HDL-C、hs-CRP及ox-LDL无显著变化;③治疗后2组患者血浆TC、LDL-C、HDL-C、hs-CRP及ox-LDL水平有显著差异。结论普罗布考能有效降低老年冠心病患者的胆固醇水平,并可显著降低血浆hs-CRP及ox-LDL水平,提示其具有较强的抗炎症及抗氧化作用。

Objective To evaluate the anti-inflammation and anti-oxidation effect of probucol on the old patients with coronary heart disease(CHD). Methods Sixty-three patients with CHD were randomly divided into treatment group with 35 subjects who received probucol 0.5g, bid, and control group with 28 subjects who never received lipid-lowering agents and antioxidants. The total period of treatment was 12 weeks. The plasma level of the highly sensitive C-reactive protein(hs-CRP )and oxidized low-density lipoprotein (ox-LDL) before and after treatment were examined. Results ①The plasma level of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol (HDL-C),hs-CRP and ox-LDL were decreased significantly in the probucol group; while no significant change in the above parameters was observed in the control group. ②There were significant differences in the above parameters between the 2 groups after treatment. Conclusions ①Probucol could improve the level of plasma lipid in the old patients with CHD; ②Probucol could reduce the plasma level of hs-CRP and ox-LDL significantly, indicating its good anti-inflammation and anti-oxidation effects.