脊髓型颈椎病术后创伤反应不同剂量甲泼尼龙治疗方案的成本-效果分析

Cost-effectiveness Analysis on Different Doses of Methylprednisolone Treatment Regimes on Postopera-tive Traumatic Reaction in Patietents of Cervical Spondylotic Myelopathy

目的:评价不同剂量甲泼尼龙治疗方案对脊髓型颈椎病前路减压术后创伤反应的经济效果。方法:选取行前路减压术的脊髓型颈椎病患者56例,给予不同剂量甲泼尼龙治疗,分为A组(18例,小剂量组,初始剂量为80mg)、B组(21例,中剂量组,初始剂量为600mg)、C组(17例,大剂量组,初始剂量为1000mg) ,分别观察各组临床症状的改善程度,并比较其成本-效果。结果:A、B、C组治疗成本(C)分别为990 00元、1339. 10元、1886. 70元;显效率(E)分别为5 56 %、14. 29 %、35. 29 % ;单位明显效果所需成本(C/E)分别为178 06元、93. 71元、53 .46元;在A组的基础上,B组和C组增加单位明显效果所需成本(ΔC/ΔE)分别为39 .99元和30 .16元。结论:C组较A组和B组的显效率有较大提高,而且单位明显效果所需成本最低,故C组剂量方案较为合理。

OBJECTIVE:To evaluate the economic effects of different doses of methylprednisolone treatment regimes on traumatic reaction in patients with cervical spondylotic myelopathy after anterior decompressive operation.METHODS:56cervical spondylotic myelopathy cases who have been subjected to anterior decompressive operation were chosen to be the sub-jects.The56cases were divided into3groups and treated with different dosage of methylprednisolone,the initial dose for group A(18cases,low dose group)was80mg;the initial dose for group B(21cases,medium dose group)was600mg and that for group C(17cases,large dose group)was1000mg,the improvement of clinical symptom of each group was observed re-spectively and the cost-effectivenesses of the three groups were compared.RESULTS:The costs of the A,B,C groups were990.00,1339.10and1886.70yuan respectively;the effectiveness rates(E)of the A,B,C groups were5.56%,14.29%and35.29%respectively;The costs for each unit of obvious effectiveness(C/E)of the A,B,C groups were178.06,93.71and53.46yuan respectively;On the basis of group A,the needed costs of group B and C were39.99and30.16yuan respectively for each obvious effectiveness unit increase(ΔC/ΔE).CONCLUSION:Compared with group A and B,the effectiveness rates of group C had a bigger increase while the needed cost for each unit of obvious effectiveness was the lowest,therefore,the dose regimen of group C is more rational.