声学密度定量技术检测儿童发热性疾病冠状动脉改变的临床研究

Clinical study of detecting changes of coronary artery with its surrounding tissues in children with infectious diseases by acoustic density quantification technology

目的 探讨声学密度定量技术检测川崎病与发热性疾病冠状动脉改变的临床意义。方法 急性期川崎病患儿68例(川崎病组),一般疾病发热组38例及正常对照组38例,测定左室后壁心包组织及左、右冠状动脉壁及其周围组织的背向散射积分(IBS),用冠状动脉壁IBS和心包IBS比值作为冠状动脉壁校正IBS(IBS% )。结果 川崎病组的IBS值和IBS%值(左冠状动脉为40. 83±5. 81和0. 83±0. 11,右冠状动脉为39. 43±5. 37和0. 80±0. 11 )均明显大于发热组(左冠状动脉为36. 54±5. 28和0. 77±0. 23,右冠状动脉为36. 19±5. 74和0. 75±0. 15 )及正常对照组(左冠状动脉为35. 79±4. 6和0. 72±0. 86,右冠状动脉为32. 35±6. 71和0. 65±0. 13),其差异有显著性意义(P<0. 01);而发热组与正常对照组之间差异无统计学意义(P>0. 05)。结论 声学密度定量技术有助于检出川崎病冠状动脉早期病变,对早期和非典型川崎病的诊断有重要价值。

Objective To explore the clinical significance of acoustic density quantification(AD) technology for detecting the changes of coronary arteries in children with Kawasaki disease and other infectious diseases. Methods Sixty eight cases with acute Kawasaki disease, thirty eight cases with other infectious disease and thirty eight cases of normal children were examined using AD technology. Integrate backscatter(IBS) and IBS%(IBS of coronary artery/IBS of pericardium) of coronary artery with its surrounding tissues were calculated. Results IBS and IBS% of Kawasaki disease children were significantly higher than that of other infectious disease children and normal children(P0.001), while IBS and IBS% of other infectious children and normal children have no significant difference(P> 0.05 ). Conclusions AD technology is useful in detecting coronary artery lesions in the patients with Kawasaki disease at early stage, which plays an important role in diagnosis of atypical Kawasaki disease at early stage.