芬太尼透皮贴剂治疗中重度癌性疼痛的疗效观察

Clinical application of transdermal fentanyl in treatment of moderate or severe cancer pain

为进一步观察芬太尼透皮贴剂(多瑞吉)对于中重度癌性疼痛的疗效、不良反应及患者生活质量的改善,对106例伴有中重度疼痛的恶性肿瘤患者,采用芬太尼透皮贴剂进行外敷治疗,记录用药前后疼痛强度、生活质量评分、不良反应以及患者对多瑞吉的偏爱情况。结果疼痛总的缓解率为92.5%(98/106),其中完全缓解47.2%(50/106),明显缓解35.8%(38/106),中度缓解9.4%(10/106)。主要不良反应有头晕、恶心、呕吐、嗜睡和便秘等。对多瑞吉偏好患者占84.9%(90/106)。初步研究结果提示,芬太尼透皮贴剂可有效地控制疼痛,不良反应较小,患者的依从性好。

The objective of this study was to evaluate the effect,side-effect, life quality changes of patients and patients’ preference of transdermal fentanyl (Durogesic) in the treatment of moderate or severe cancer pain. A total of 106 tumor patients with moderate or severe cancer pain were treated with transdermal fentanyl. The pain intensity, side-effect, quality of life and patients’ preference were studied at the beginning and end of the therapy. The total remission rate of pain was 92.5%(98/106), of which complete remission rate was 47.2%(50/106),obvious remission rate 35.8%(38/106) and moderate remission rate 9.4%(10/106). The side-effects included dizziness, nausea, vomiting ,lethargy and constipation etc. Patients’ preference was 84.9%(90/106). In conclusion, transdermal fentanyl is effective in relieving cancer pain with slight side-effects. Patients’ preference is good.