可溶性细胞间黏附分子-1在良恶性胸腔积液中的检测

Levels of sICAM-1 in benign and malignant pleural effusion

目的:通过检测正常人血清和结核性胸膜炎、癌性胸腔积液患者血清及胸腔积液中可溶性细胞间黏附分子- 1(sICAM-1)水平,探讨其对鉴别良、恶性胸腔积液的意义。方法:采用酶联免疫吸附法(ELISA)检测20例正常人、20例结核性胸膜炎和17例恶性胸腔积液患者血清及胸腔积液中sICAM 1的水平。结果:结核性胸膜炎、恶性胸腔积液患者血清sICAM -1水平高于正常对照组,t值分别为9. 031和10. 816,P均<0 .05;恶性胸腔积液sICAM 1水平明显高于结核性胸腔积液,t=4 943,P<0 .05。结论:sICAM -1可能参与了结核性和肿瘤性胸膜病变的免疫病理生理过程,胸腔积液中sICAM -1 的检测可作为临床上鉴别良、恶性胸腔积液的一项参考指标。

OBJECTIVE:To explore the clinical significance of the level of sICAM-1 in sera and pleural effusions for distinguishing benign from malignant pleural effusions. METHODS: sICAM-1 levels in sera and pleural effusions of 20 normal people, 20 patients with tuberculous pleural effusions and 17 patients with malignant pleural effusions were measured with a specific enzyme-linked immunosorbent assay. RESULTS: The serum levels of sICAM-1 in benign and malignant effusions were both significantly higher than that in the control group,t=9.031, 10.816, both P<0.05. The level of sICAM-1 in malignant effusions was significantly higher than that in tuberculous effusions, t=4.943, P<0.05. CONCLUSIONS: sICAM-1 might involve in immunopathological process of tuberculous and malignant pleural effusions. The measurement of sICAM-1 of pleural effusions is useful to distinguishing tuberculous from malignant pleural effusions.