整合素连接激酶在非小细胞肺癌中的表达及意义

EXPRESSION AND SIGNIFICANCE OF INTEGRIN-LINKED KINASE IN NON-SMALL CELL LUNG CANCER

目的 了解整合素连接激酶(intergrin- linked kinase ILK)在非小细胞肺癌中的表达情况,与临床病理特征之间的关系及与非小细胞肺癌患者预后的关系并探讨其意义。方法 采用免疫组织化学SP法和免疫蛋白印迹法检测ILK在101例非小细胞肺癌(60例鳞癌,41例腺癌)中的表达。结果 (1)ILK在非小细胞肺癌组织中的表达高于正常组织且在鳞癌组织中ILK的表达随着分化程度的降低而提高;(2)ILK的表达与临床分期,淋巴结转移等临床病理特征之间无联系(3)ILK的不同表达与非小细胞肺癌患者的预后无关。结论 目前国内外尚未有ILK在肺癌中的研究,我们的研究表明ILK在非小细胞肺癌中的表达与非小细胞肺癌组织的组织类型来源和恶性程度有关,并可能参与了非小细胞肺癌的发生发展过程。

Objective To investigate the expression and significance of intergrin-linked kinase (ILK) in non-small cell lung cancer (NSCLC) and the correlation between ILK expression and clinicopathological characteristics and prognosis of NSCLC. Methods ILK protein was detected by immunohistochemistry and western blotting in 101 cases of NSCLC. Results (1) The expression of ILK protein was stronger in NSCLC than in normal lung tissues, and also stronger in poorly than well differentiated squamous cell cancer. (2) The expression of ILK was unrelated with the clinicopathological characteristics. (3) The expression of ILK is not correlated with the prognosis of NSCLC patients. Conclusion Our research shows that ILK protein expression is stonger in NSCLC than in normal lung tissues and increases in squamous cell lung cancer with the decrease of its differentiation. It is concluded that ILK may contribute to the progression of squamous cell lung cacner ILK is not correlated with the clinical characteristics and the prognosis of lung cancer patients.