慢性胃炎患者粘膜内EGF和TFF1的表达及G细胞的相关研究

EXPRESSION OF EGF AND TFF1 IN THE MUCOSA OF PATIENTS WITH CHRONIC GASTRITIS AND ASSOCIATED STUDY OF G CELLS

目的 探讨EGF和TFF1在慢性胃炎患者胃窦粘膜内的表达及G细胞相关研究。方法 免疫细胞化学。结果 EGF和TFF1在慢性胃炎粘膜内的表达与正常对照组相比均有减弱或消失, 而且有显著性差异(P<0. 01)。在萎缩性胃炎的肠化区EGF和TFF1均为阴性, 但与其相邻的腺体内TFF1 仍为阳性反应。G细胞数目在Hp+ 和Hp 组之间无显著性差异, 与正常对照组比较亦无差异(P>0 .05); 但萎缩性胃炎的G细胞显著减少, 与正常对照组有差异(P<0. 01)。结论 慢性胃炎粘膜内的EGF和TFF1表达减弱或消失与Hp或其它致病原有关。肠化区内的TFF1 消失, 可能与细胞恶变有关。Hp+组患者的G细胞无增加。

Objective To investigate the expressions of EGF and TFF1 in the antrol mucosa with chronic gastritis and relative to G cell study. Methods Immunocytochemical technique was used in this study. Results The expressions of EGF and TFF1 in the antrol mucosa of patients with chronic gastritis were weak or absent and there were significant differences as compared with the control group (P<0.01). In the intestinal metaplasia both EGF and TFF1 were negative, but TFF1 was positive in adjacent glands. The number of G cells showed no significant difference between Hp~ +and Hp groups and the control group (P>0.05), but much less in atrophic gastritis than in the control group (P<0.01). Conclusion The expression of EGF and TFF1 in chronic gastritis is weak or absent, which may be related to Hp or other pathogens. The absence of TFF1 in the intestinal metaplasia may be associated with cell malignancy. The number of G cells in the Hp~ +patients shows no increase.