摘要
用离体动脉条，探讨速效救心丸扩张血管的机理。速效救心丸2mg／ml对去甲基肾上腺素、氯化钾、组织胺、乙酰胆碱、5-羟色胺诱发动脉条收缩均有明显的拮抗作用。不能使去甲肾上腺素量－效曲线平行右移，但降低最大效应，呈非竞争拮抗。它能使氯化钾、氯化钙量－放曲线平行右移，最大效应降低，呈非竞争拮抗。其特点与戊脉胺类似，提示速效救心丸具有钙拮抗作用。
Suxiaojiuxin pill' at a dose of 2mg/ml obviously inhibited the contraction of isolated rabbit aortic stripes induced by high K+, NA, Ach, His and 5-HT. In comparison with phentolamine, the 'pill' did not shift the dose-response curve of NA, but depressed maximum response in a none competititve manner. However, similar to verapamil, it shifted high K+and Ca++-free high K+ dose response curve to the right at doses of 0.2~0.4mg/ml. PEG as a solvent did not show any effect in the all tests. These results indicated that 'Suxiaojiuxin pill' has a Ca++ antagonistic effect in a none competitive manner, mainly by blocking Ca++entry through the potential dependant channel though at high concentrations it may also influenced the NA activated receptor operated channel (ROC ),
出处
《中草药》
CAS
CSCD
北大核心
1994年第2期84-86,共3页
Chinese Traditional and Herbal Drugs
