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干细胞移植心肌再生及其细胞因子分泌研究进展

Recent Development on Transplantation of Stem Cells for Myocardium Regeneration and the Production of Cytokine
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摘要 干细胞具有多向分化的潜能,可以被诱导分化成心肌细胞,代替心肌梗死后死亡的心肌细胞,改善心功能,并且干细胞能分泌一些细胞因子,它们通过增加血管密度、减少心肌重构、防止细胞凋亡等在提高心功能上发挥了重要的作用。 Stem cells have potential of differentiation that can improve cardiac function by being induced to diffe- rentiate into myocardium to replace the dead cells after cardiac infarction and produce some kinds of cytokines that can increase vascular density, decrease remodeling and prevent apoptosis of myocardium. These functions of cytokines play an important role in the therapy of infarcted myocardium by the regeneration of myocardium.
作者 马南 钟竑
机构地区 上海第二医科大学新华医院胸心外科
出处 《上海第二医科大学学报》 CSCD 北大核心 2005年第4期424-426,共3页 Acta Universitatis Medicinalis Secondae Shanghai
关键词 干细胞 分化 心肌细胞 细胞因子 研究进展 stem cells differentiation myocardium cytokine
分类号 R654.2 [医药卫生—外科学]
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参考文献19

  • 1钟竑,朱洪生,张臻.梗死心肌骨骼肌卫星细胞移植后心肌细胞结蛋白变化[J].中国胸心血管外科临床杂志,2000,7(4):245-248. 被引量：9
  • 2Fodor WL. Tissue engineering and cell based therapies, from the bench to the clinic: the potential to replace, repair and regenerate[J]. Reprod Biol Endocrinol, 2003, 13;1(1): 102.
  • 3Kehatl, Kenyagin Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes[J]. J Clin invest, 2001,108(3): 407-414.
  • 4Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro[J]. J Clin Invest, 1999,103(5): 697-705.
  • 5Jochen ME, Peterson KL. Rebuliding damaged heart[J]. Circulation, 2002,105: 1720-1726.
  • 6Kamihata H, Matsubara H, Nishjue T, et al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic lLigands and cytokines[J]. Circulation, 2001,104(9): 1046-1052.
  • 7Strauer BE, Brehm M, Zeus T, et al. Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction[J]. Dtsch Med Wochenschr, 2001,126(34-35): 932.
  • 8Siminiak T, Grygielska B, Jerzykowska O, et al. Autologous bone marrow stem cell transplantation in acute myocardial infarction-report on two cases[J]. Kardiol Pol, 2003,59(12): 502-510.
  • 9Assmus B, Schachinger V, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI) [J]. Circulation, 2002, 10;106(24): 3009-3017.
  • 10Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regene-rate infracted myocardium[J]. Nature, 2001,410: 701-705.

二级参考文献12

  • 11，Li ZL, Mericskay M,Agbulut O, et al.Desmin is essential for the tensile strength and integrity of myofibrilsbut not for myogenic commitment, differentiation, and fusion of skeletal muscle. J CellBiol, 1997, 139(1):129-144.
  • 22，Schaper J, Froede R, Hein St, et al. Impairment of the myocardial ultrastructure andchanges of the cytoskeleton in dilated cardiomyopathy. Circulation, 1991, 83(2):504-514.
  • 33，Dorfman J, Duong M, Zibaitis A, et al. Myocardial tissue engineering with autologousmyoblast implantation. J Thorac Cardiovasc Surg, 1998, 116(3):744-751.
  • 44，Schwarz ER, Patterson M, Kloner RA. Cardiomyocyte transplantation——a cellreplacement for repair of myocardial infarction? Z Kardiol, 1998, 87(1):1-7.
  • 55，Smith MJL, Mcgeachie JK. The identification of myogenic cells in skeletal muscle, withemphasis on the use of tritiated thymidine autoradiography and desmin antibodies. J Anat,1998, 192(1):161-171.
  • 66，Reinecke H, Zhang M, Bartosek T, et al. Survival, integration, and differentiation ofcardiomyocyte grafts: a study in normal and injured rat hearts. Circulation, 1999, 100(7)：193-202.
  • 77，Murry CE, Wiseman RW, Schwartz SM, et al. Skeletal myoblast transplantation for repairof myocardial necrosis. J Clin Invest, 1996, 98(11):2512-2523.
  • 88，Robinson SW, Cho PW, Levitsky HI, et al. Arterial delivery of genetically labelledskeletal myoblasts to the murine heart:long-term survival and phenotypic modification ofimplanted myoblasts. Cell Transplant, 1996, 5(1):77-91.
  • 9Schwarz ER,Patterson M,Kloner RA.Cardiomyocyte transplantation-a cell replacement for repair of myocardial infarction[].Zeitschrift fur Kardiologie.1998
  • 10Unger EF,Banai S,Shou M,et al.Basic fibroblast growth factor enhances myocardial collateral flow in a canine model[].American Journal of Physiology Heart and Circulatory Physiology.1994

共引文献14

上海第二医科大学学报
2005年 第4期

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