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Pax5在早期B细胞定向分化发育中的作用 被引量：2

Role of Pax5 in Early B Lineage Commitment and Development
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摘要 B细胞的定向分化是多个转录因子参与的复杂调控过程,其中Pax5基因编码的B细胞特异性激活蛋白(BSAP)在B细胞的早期定向分化中起着决定性作用。本文着重从Pax5激活多个B系特异性基因、抑制非B系基因的表达和Pax5-/-proB细胞的多向分化潜能等方面,综述Pax5在B细胞早期定向分化中的作用。 Differentiation of hematopoietic progenitors into the B-lymphocyte lineage requires co-ordination of a complex network of transcriptional regulators. The Pax5 gene, which encodes the B cell specific activator protein (BSAP), is specially expressed in B-lymphoid lineage cells. Pax5 is essential for initiating B cell lineage commitment. This review addresses the role of Pax5, as an activator or repressor, in activating the B cell lineage specific genes and repressing the promiscuous transcriptions of lineage inappropriate genes, as well as the pluripotency and self-renewing capacity of hematopoietic stem cell features in Pax5 -/- pro-B cells.
作者 袁向亮 沈立松
机构地区 上海第二医科大学新华医院上海儿童医学中心实验诊断中心
出处 《上海第二医科大学学报》 CSCD 北大核心 2005年第4期427-430,共4页 Acta Universitatis Medicinalis Secondae Shanghai
关键词 PAX5 B细胞特异性激活蛋白 B淋巴细胞 分化 Pax5 B-cell-specific activator protein B lymphocyte differentiation
分类号 Q253 [生物学—细胞生物学]
  • 相关文献

参考文献19

  • 1Rahman M, Hirabayashi Y, Ishii T, et al. A repressor element in the 5'-untranslated region of human Pax5 exon 1A [J]. Gene, 2001, 263(1-2): 59-66.
  • 2Jin ZX, Kishi H, Wei XC, et al. Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax5 in immature B cells [J]. J Immunol, 2002, 169(7): 3783-3792.
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  • 5Wallin JJ, Gackstetter ER, Koshland ME. Dependence of BSAP repressor and activator function on BSAP concentration [J]. Science, 1998, 279:1961-1964.
  • 6Eberhard D, Jimenez G, Heavey B, et al. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family [J]. EMBO J, 2000, 19(10): 2292-2303.
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同被引文献31

  • 1李文才,赵武干,高冬玲,张岚,赵阿红,庞霞.弥漫性大B细胞淋巴瘤的临床病理观察及其B细胞来源分析[J].郑州大学学报（医学版）,2007,42(4):662-665. 被引量：1
  • 2水若鸿,杨文涛,孙孟红,施达仁,朱雄增.套细胞淋巴瘤石蜡包埋组织中细胞周期蛋白D1和t(11;14)易位检测的临床病理意义[J].中华病理学杂志,2003,32(4):337-341. 被引量：21
  • 3张蓓,袁向亮,帖利军,叶启东,汤静燕,沈立松.PAX5/BSAP在儿童急性白血病细胞和血液肿瘤细胞株中的表达研究[J].中华检验医学杂志,2005,28(11):1131-1135. 被引量：1
  • 4Barberis A,Superti-Furga G,Vitelli L,et al.Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin[J].Genes Dev,1989,3(5):663-675.
  • 5Rahman M,Hirabayashi Y,Ishii T,et al.A repressor element in the 5'-untranslated region of human Pax-5 exon IA[J].Gene,2001,263(1-2):59-66.
  • 6Busslinger M,Urbanek P.The role of BSAP (Pax-5) in B-cell development[J].Curt Opin Genet Dev,1995,5(5):595-601.
  • 7Roberts EC,Deed RW,Inoue T,et al.Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding[J].Mol Cell Biol,2001,21 (2):524-533.
  • 8Maier H,Hagman J.Roles of EBF and Pax-5 in B lineage commitment and development[J].Semin Immunol,2002,14(6):415-422.
  • 9Wallin JJ,Gackstetter ER,Koshland ME.Dependence of BSAP repressor and activator function on BSAP concentration[J].Science,1998,279(5358):1961-1964.
  • 10Eberhard D,Jimenez G,Heavey B,et al.Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family[J].EMBO J,2000,19(10):2292-2303.

引证文献2

二级引证文献8

上海第二医科大学学报
2005年 第4期

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