摘要
高浓度葡萄糖可增加内皮细胞内反应性导其凋亡;银杏叶提取物可提高内皮细胞在高糖环境下的活力,降低其凋亡率,可能与其通过抗氧化作用及下调泛素介导的胞浆内蛋白水解系统有关。
High glucose may induce apoptosis of ECV-304 cells via increasing intracellular reactive oxygen species (ROS) formation, in which ubiquitin (Ub) seems to be involved. Extract of Ginkgo biloba attenuates the apoptosis of endothelial cells exposed to high glucose concentration, which is at least partly via inhibiting ROS formation and Ub mRNA expression.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2005年第2期171-172,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
银杏叶提取物
血管内皮细胞
细胞凋亡
葡萄糖
糖尿病
High glucose concentration
Apoptosis
Reactive oxygen species
Extract of Ginkgo biloba
