抗感染重组合异种骨的动物实验

Animal experimental studies of anti-infective reconstituted bone xenograft

【目的】检测抗感染重组合异种骨安全性。【方法】对抗感染重组合异种骨进行急性毒性试验、过敏试验、肌内埋植试验和骨内埋植试验。【结果】抗感染重组合异种骨不引起小鼠急性毒性,未引起豚鼠过敏反应,在兔骨内埋植和鼠肌内埋植未引起淋巴细胞、炎性细胞浸润。【结论】抗感染重组合异种骨可以安全、有效的试用于临床。

To test safety of anti-infective reconstituted bone xenograft productsPerformed acute toxicity,hypersensitivity,intraosseous and intramusular implantation test for anti-infective reconstituted bone xenograft.Absent acute toxicity in mouse ;absent allergic reaction in guinea pig; intraosseous implant in rabbit or intramuscular implant in mouse did not lymphocyte and inflammatory cell infiltration.[Conclusion]Anti-infective reconstituted bone xenograft being used safely and validly in clinical settings.