摘要
目的观察马钱子、天南星水提取液对小鼠移植性肿瘤H22的抑瘤作用,探讨这两种中药在肿瘤临床应用的合理性。方法昆明种小鼠,接种H22后随机分为对照组、环磷酰胺组及给药高、低剂量组,观察药物对肿瘤的抑制作用及对动物体重、免疫器官重量的影响。结果与对照组相比较,环磷酰胺的抑瘤率达到56.6%(P<0.01),同时小鼠增重减慢,胸腺、脾也受到显著抑制;高剂量给药组的抑瘤率为38.9%(P<0.05),低剂量组作用不明显。但两剂量组小鼠体重及免疫器官重量均未见明显改变。结论马钱子、天南星水提取液在一定剂量下对小鼠移植性肿瘤H22的生长有明显的抑制作用,且对小鼠的免疫器官无明显损害,其在肿瘤临床中的应用具有一定的合理性。
Objective To observe the tumorostatic activity of aqueous extracts of nux vomica and rhizoma arisaematis on transplanted tumor H22 in mice,and reveal the rationality of using the two medicines in clinical tumor therapy.Methods Mice of Kunming species which had got the transplanted tumor H22 were divided randomly into four groups:the control group,cyclophosphamide group,high-dose trial group,and low-dose trial group.All of the mice received the medicines through gavage;tumorostatic activities,as well as the changes of animal weights and their immune organ's weight were recorded.Results Cyclophosphamide group had a tumorostatic rate 56.6%(P<0.01),but meanwhile an evident inhibitory effect on the thymus gland,spleen,and body weight was seen.High-dose trial group had a tumorostatic rate 38.9%(P<0.05);low-dose trial group showed no noticeable effect;there were no evident changes in animal weights and their immune organs in the two trial groups.Conclusion Aqueous extracts of nux vomica and rhizoma arisaematis in a certain dosage show a marked inhibitory effect on the murine transplanted tumor H22,no harm to their immune organs,implying that using these Chinese medicines in clinical tumor therapy is rational.
出处
《中国药物与临床》
CAS
2005年第4期272-274,共3页
Chinese Remedies & Clinics
