蒲葛舒胃灵对实验性胃溃疡作用的研究

Study on action of pugeshuweiling on experimental gastric ulcer

目的研究蒲葛舒胃灵抗实验性胃溃疡的作用。方法采用应激性胃溃疡模型、吲哚美辛致大鼠急性胃黏膜损伤模型、大鼠幽门结扎胃溃疡等模型观察蒲葛舒胃灵抗胃溃疡作用、对醋酸所致小鼠扭体反应的影响和体外抗幽门螺杆菌的作用。结果蒲葛舒胃灵能减少大鼠实验性胃溃疡面积,抑制醋酸所致小鼠扭体反应次数,对幽门螺杆菌具有明显抑制作用。结论蒲葛舒胃灵有显著的抗胃溃疡作用,实验结果与该药用于治疗胃溃疡的功效吻合。

Objective To study the action of pugeshuweiling(a TCM preparation) on the experimental gastric ulcer.Methods Water immersion and restraint stress-induced gastric injury was used as the experimental model of acute gastric ulcer,the acute gastric mucosal damage model in rats was induced by indomethacin,the rat gastric ulcer models induced by pyloric ligature.Ulcer-preventive action,effect on mice′s twisting motion caused by acetic acid,and in vitro counteraction to Helicobacter pylori were detected as to this medicine.Results Pugeshuweiling showed to be able to reduce area of experimental gastric ulcer,reduce the twisting motion,and inhibit the growth of Helicobacter pylori in vitro.Conclusion Pugeshuweiling has antiulcer effect on rats,the experimental data are identical with pugeshuweiling′s curative effect on gastric ulcer.