毛细管气相色谱法测定氯唑沙宗片含量

Determination of Chlorzoxazone Tablets by GC

目的 测定氯唑沙宗片中氯唑沙宗含量。方法 采用毛细管气相色谱法,色谱柱:OV -I弹性石英毛细管柱(30m×0 . 2 5mm,0 . 1μm),汽化室温度:2 2 0℃,检测器温度:2 5 0℃;检测器:FID检测器;载气:氮气;流速:2 . 5ml·min-1,尾吹:2 0ml·min-1,分流比5∶1。结果 氯唑沙宗15～4 0 μg·ml-1(r =0 9998)范围内呈良好线性关系,平均回收率为10 0 . 2 %。结论 该方法测定氯唑沙宗含量准确、可靠,回收率高。

Objective To determine the content of Chlorzoxazone Tablets.Methods GC system,including OV-1 FSOT capillary column and FID,was used.Results Chlorzoxazone showed a good lineariy in 15～40μg·ml -1(r=0.9998).The average recovery was 100.2%.Conclusion This methods is accurate and reliable with a high recovery of Chlorzoxazone.