摘要
目的 观察短期胰岛素强化治疗对初诊的2型糖尿病患者的血糖控制及胰岛β细胞功能的改善。方法 对初诊的2型糖尿病患者29例进行2周的强化胰岛素治疗。分析比较其治疗前后空腹血糖(FPG) 及餐后2小时血糖(2HPG)、糖化血红蛋白(HBA1C)、空腹胰岛素和餐后2小时胰岛素, 由Homa模型计算Homa-β功能指数和Homa-IR (胰岛素抵抗指数), 并对治疗成功组患者随访3个月。结果 2周的胰岛素强化治疗可以逆转初诊2型糖尿病患者β细胞的功能。结论 短期胰岛素强化治疗对初诊2型糖尿病患者血糖控制有良好的疗效。
Objective To evaluate the effect of short-term intensive insulin treatment on β-cell function and glycolic control on newly diagnosed type 2 diabetes mellitus patients.Methods Twenty-nine newly diagnosed type 2 diabete mellitus patients were treated with intensive insulin for two weeks.Studying and comparing fasting plasma glucose (FPG), 2 hour postprandial glucose(2hPG) , glycostylated hemoglobinA1C (HbA1C), Fasting insulin (FINS) and 1 hour postprandial insulin (INS60) before and after the insulin treatment and calculating Homa-βand Homa IR by Homa model, then following up the patients on successful treatment for three months.Results Two weeks' intensive insulin treatment can reverse the βcell function of type 2 diabetes mellitus patients' .Conclusion There are excellent effect on glycolic control of newly diagnosed type 2 diabetes mellitus patients by short-term insulin treatment .
