摘要
用沙土鼠制成缺血及再灌注模型，观察到在缺血５０ｍｉｎ时脑能量代谢明显障碍，再灌注３Ｏｍｉｎ时有所改善，而在再灌注１２０ｍｉｎ时发生迟发性能量代谢恶化。吡硫醇（脑复新）可明显改善缺血５０ｍｉｎ时的能量代谢，并能纠正再灌注１２０ｍｉｎ时的迟发性能量代谢恶化。本文讨论吡硫醇对脑损伤保护作用的机制。
Abstract In the model of ischemia and reperfusion on Gerbil brains,it was found that energy metabolism was inhibited after 50 min of ischemia which was resuming after 30 min of reperfusion,but which went into secondary deterioration after 120 min of reperfusion.Pyritinol could markedly improve energy metabolism after 50 min of ischemia,and also suppress the development of secondary deterioration in energy metabolism after 120 min of reperfusion.The protective effect of pyritinol on brain ischemic injury and its mechanisms was discussed.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1994年第1期8-10,共3页
Journal of Apoplexy and Nervous Diseases
