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膀胱癌组织中金属硫蛋白表达的意义 被引量:2

THE STUDY OF METALLOTHIONEIN EXPRESSION IN BLADDER CANCER
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摘要 目的:探讨金属硫蛋白在膀胱癌中表达的意义。方法:收集10 3例膀胱癌石蜡切片,免疫组织化学染色。结果:金属硫蛋白在高分级、高分期、非乳头状癌中表达率高。结论:金属硫蛋白在膀胱癌中的过度表达与膀胱癌的病理分化程度有关。 Objective: To study the signif icance of metallothionein expression in bladder cancer. Methods: 103 cases of bladder cancer were collected, then their sections were p araffined, and immunohistochemistry was used. Results: T he positive rate of metallothioneins in high grade and high stage bladder cancer is high. Conclusion: Metallothionein is excessively exp ressed in bladder cancer, and its expression is related with pathologic differen tiation degree.
出处 《泸州医学院学报》 2005年第2期143-144,149,共3页 Journal of Luzhou Medical College
关键词 金属硫蛋白 免疫组织化学 膀胱癌 Metallothioneins immunohistochemistry Bla dder cancer
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参考文献4

  • 1Karin M.Metallothioneins:Proteins in search of function[J].Cell,1985;41:9.
  • 2Saga Y,Hashimoto H,Yachiku S,et al.Immunohisto chemical expression of metallothionein in human bladder canceri:Correlation with histopathological parameters and Patiert Survival[J].Urol,2002;168(5):2227.
  • 3Zhang X H,Jin L,Takena Ka I,et al.Localization of zinc and metallothionein in the rat bladder epithelium during carcinogenesis induced by N-buty-N-C4-hydroxybutyl nitrosamine[J].Urol Res,1996;24(3):279.
  • 4Sens MA,Somji S,Lamm DL,et al.Metallothinein iaoform 3 as a potential biomarker for human bladder cancer[J].Environ Perspect,2000;108(5):413.

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