摘要
目的:探讨Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达及其与预后的关系。方法:选取临床病理资料完整并随访5年以上的137例乳腺癌病例,采用SP免疫组织化学技术检测乳腺癌组织中的Maspin、BCSG1、c-erbB-2蛋白的表达情况,结合临床及病理形态学资料用COX模型分析Maspin、BCSG1、c-erbB-2表达对预后的影响。结果:Maspin、BCSG1、c-erbB-2蛋白在乳腺癌组织中的阳性表达率分别为48.9%,67.2%,27.7%三者与生存时间显著相关(P<0.01)。结论:Maspin、BCSG1、c-erbB-2蛋白在乳腺癌中的表达与患者的生存期密切相关,可作为预测乳腺癌预后的参考指标。
Objective: To assess the relationship between the Maspin, BCSG1 and c-erbB-2 expression and the prognosis in breast cancer. Methods: The expression of ER, PR, Maspin, BCSG1, c-erbB-2 were determined with the SP immunohisto-chemical method in 137 cases with invasive breast cancer followed up over 5 years. Cox model was used to analyze the effect of Maspin, BCSG1 and c-erbB-2 expression and the clinopathological manifestations and prognosis in breast cancer. Results: The expression rate of Maspin, BCSG1 and c-erbB-2 was 48.9%, 67.2% and 27.7%, respectively, which were in relation with the survivals (P<0.01). Conclusion: The expression of BCSG1, c-erbB-2 and Maspin is closely related to the survival rate and can be used as the predictor of prognosis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第8期431-434,共4页
Chinese Journal of Clinical Oncology
基金
河北省卫生厅科研基金资助(编号:02276103D-12)
