原发性胃肠道非霍奇金淋巴瘤45例分析

Clinical Study of Primary Gastrointestinal Non-Hodgkin's Lymphoma: A Report of 45 Cases

目的:对原发性胃肠道非霍奇金淋巴瘤的临床特征、诊治、预后进行探讨。方法:回顾性分析45例原发性胃肠道淋巴瘤。结果:Kaplan-Meier生存分析结果,2年生存率为82.80%,不同病理类型生存曲线有显著性差异。COX多因素分析,总生存期在不同病理类型有显著差异,而在性别、年龄、分期、有无B症状及浸润深度间无显著差异。结论:手术联合化疗治疗早期胃肠道淋巴瘤疗效较好。胃肠道非霍奇金淋巴瘤的病理分型与预后密切相关。

Objective: To analyze the clinical manifestations, diagnosis, therapy and prognosis of primary gastrointestinal non-Hodgkin's lymphoma(PGIL). Methods: Forty-five cases of astrointestinal Non-Hodgkin'slymphoma were studied retrospectively. Results: The group's two-year survival rate was 82.8%. Significant differences were manifested among groups of different histological classification by Log-rank test. Cox multivariate analysis revealed that histological type worked as a prognostic factor other than indices like sex, age, staging, presence of B-symptoms and level of infiltration. Conclusion: Regular therapy of resection combined with chemotherapy may improve the treatment for patients with PGIL at early stage. The histological type of the PGIL is one of the most important prognostic factors.