摘要
目的探讨低蛋白血症对药物性肝功能损害的影响。方法对2001年9月至2003年5月在本院住院治疗的初治肺结核患者258例。根据其年龄、性别和乙肝两对半情况,进行1∶1配对的病例-对照研究。结果258例肺结核患者中出现肝功能损害54例(20.9%),病例组出现药物性肝功能损害34例(26.4%),对照组20例(15.5%,P=0.032)。低蛋白血症与抗结核治疗中出现肝功能损害有关联,其优势比(OR)为2.0,但是在药物性肝功能损害的发生时间和损害程度上均无明显差异。结论在临床上,对合并低蛋白血症结核病患者治疗时,应注意监测其肝功能变化以及注意改善其低蛋白血症的状态,减少药物性肝功能损害的发生。
Objective To study influence of hypoproteinem ia to drug-induced hepatitis during the chemotherapy of tuberculosis.Method A matched case-control study accord ing to age,sex and hepatitis of 258patients with first-treatment pulmonary tuberculosis h ospitalized in our department from S ep.2001to Sep.2002.Results54patients(20.9%)had drug-induced hepatitis after tr eating with anti-tuberculosis drugs.There were 34patients(26.4%)in the case group and 20patients in the control g roup(15.5%,P=0.032).There is a significant correlation between hypoproteinemia and drug-induced hepatitis(OR =2.0),but no correlation between the occu rred time and lesion.Conclusions In the treatment of pulmonary tuberculosis patients with hypoproteinemia by a nti-tuberculosis drugs,the change of liver functions must be monitored and the s tatus of hypoproteinemia must be imp roved in order to reduce the occurren ce of drug-induced hepatitis.
出处
《热带医学杂志》
CAS
2005年第2期139-141,共3页
Journal of Tropical Medicine
基金
广东省广州市科技局课题(No.2003Z1-E001)。
关键词
抗结核药物
结核/肺
肝功能损害
低蛋白血症
hypoproteinemia
pulmonary tuberculosis
therapeutics
drug-induced hepatitis
