血清CEA检测在结直肠癌患者中的临床意义

Clinical Significance of the Detection of Serum CEA in Colorectal Cancer

目的探讨血清CEA的检测对大肠癌诊断的临床应用价值。方法对88例大肠癌患者、40例结直肠良性疾病患者、30例健康成人的CEA检测水平进行分析。结果恶性肿瘤血清CEA检出率与健康组、良性疾病组相比有显著差异(P<0.01);CEA在结肠癌和直肠癌中检出率无显著性差异(P>0.90);血清CEA水平与病理分期(Dukes分期)、淋巴结转移、远处转移呈正相关,均有密切关系(P<0.005);与年龄、性别、肿瘤大小、组织学分型、分化程度均无显著相关性(P均>0.1),术前CEA水平与术后比较,两者有显著性差异(P<0.01)。结论CEA是结直肠癌的一个重要的诊断指标,同时有利于判断病情发展和肿瘤侵润程度。

Objective To investigate the clinical signifi cance of serum CEA in patients with colorectal carcinoma.Method Serum levels of CEA in 88patients suf fering from colorectal cancer,40patients suffering from colorectal ad enoma and 30healthy persons were studied.Results The positive rates of CEA in patients suffering from colorectal cancer,patients suffering from colorectal adenoma and healthy persons were rem arkably different (P<0.01).The level of serum CEA was correlated to the pathological stages(Dukes staging),lymph nodes metastases,and distant metastases(P<0.01).The difference between preoperative and postoperative levels of serum CEA was of highly significance(P<0.01).Clinicopathological analysis of p atients showed that serum levels of CEA were associated neither with age,sex,nor with sites,sizes,histological classification and differentiatio n grades(P<0.01).Conclusion The results suggested that the level of serum CEA is an valuable marker for the diagnosis of colon ic carcinoma and evaluation of patie nt's conditions.