摘要
目的 探讨DPC4 /Smad4在胰腺癌组织中的表达及意义。方法 采用免疫组织化学SABC法,对34例胰腺癌和慢性胰腺炎组织进行DPC4 /Smad4表达水平研究。结果 DPC4 /Smad4蛋白在胰腺癌组织中的阳性表达低于慢性胰腺炎组织(P <0 .0 5 ) ,患者性别、年龄、肿瘤大小、部位、病理分型、组织学浸润之间的表达差异无统计学意义(P >0 .0 5 )。结论 DPC4作为一种抑癌基因,其改变对胰腺癌的发生、发展可能起重要作用。
Objective To explore the expression of DPC4/Smad4 in pancreatic carcinoma. Methods DPC4/Smad4 was detected in tissue sample from 34 cases with pancreatic carcinoma and 34 cases with chronic pancreatitis using SABC immunohisto-chemical methods. Tissue sample positive to DPC4/Smad4 protein was analysed statistically by SPSS10.0. Results DPC4/Smad4 was found to be significantly higher in chronic pancreatitis tissue than that in pancreatic carcinoma(P<0.05). DPC4/Smad4 was not found to have any correlation with sex, age, size and site and site of tumor ,clinical stage or pathological type. Conclusions DPC4/Smad4 may be a tumor suppressive gene, Its alteration may play an important part during tumorigenesis and development of pancreatic cancer.
