摘要
目的 探讨不稳定型心绞痛(UA)患者血清肿瘤坏死因子-α(TNF -α)和白细胞介素- 6 (IL - 6 )的变化关系。方法 测定4 5例UA患者(UA组)和36例正常对照组(对照组)血清TNF -α和IL - 6浓度,并进行比较分析。结果 UA组血清TNF -α和IL - 6水平明显高于对照组(P <0 .0 1) ;UA组患者12周后发生急性心肌梗死(MI)者TNF -α和IL - 6水平明显高于无心肌梗死者,有显著性差异(P <0 .0 1) 。结论 UA患者血清TNF -α、IL - 6水平明显升高,12周后发生MI的患者血清TNF -α、IL - 6水平明显高于无MI者,血清TNF -α、IL - 6可作为冠心病预后的参考指标。
Objective To explore the variety relation of the tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in patients with unstable angina(UA). Methods The serums concentration of TNF-α and IL-6 were determined in 45 patients with UA (UA group) and 36 normal persons (contral group).Results The serums levels of TNF-α and IL-6 in UA group were significantly higher than contral group(P<0.01). The serums levels of TNF-α and IL-6 of the cases of acute myocardial infarction in UA group were significantly higher than others(P<0.01) after 12 weeks. Conclusions The serum level of TNF-αand IL-6 can be the prognostic index to coronary heart disease.
