2Treede NO,Meyer RA. Peripher and central mechanisms of cutaneous hyperalagesia[J]. Prog Neurobiol,1992,38:392 -421.
3Tohn BD,JulieA,MartinJ,et al. Vanilloid receptor- 1 is essential for informatory thermal hyperalgesia[J]. Nature,2000,405:183 - 187.
4Mamet J,Lazdunski M,Voilley N. How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons[J]. J Bio Chem,2003,278(49) :48907-48913.
5Voilley N,Weille J D,MametJ,etal. Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors[J ].J Neurosci,2001,21: 8026-8033.
6XuGY,Huang LYM. Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons[J]. J Neurosci,2002,22: 93-102.
7Gold MS,Relichling D,Shuster M,et al. Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors[J].PNAS,1996,93: 1108-1112.
8Woolf CJ,Salter MW. Neuronal plasticity: increasing the gain in pain[J]. Science,2000,288:1765-1768.
9Stucky CL,Gold MS,Zhang X. Mechanisms of pain[J].PNAS,2001,98:11845-11846.
10Caterina MJ,Marker A. The capsaicin receptor: a heat-activated ion channel in the pain pathway[J]. Nature,1997,389:816-824.
二级参考文献20
1[1]Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature, 1997, 398: 816～824.
2[2]John BD, Julie G, Martin J, et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature, 2000, 405:183～187.
3[3]Caterina MJ, Leffler A, Malmberg AB, et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science, 2000, 288:306～313.
4[4]Bevan S, Szolcsanyi J. Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends in Neurosci, 1990, 11:330～333.
5[5]Welch JM, Simon SA, Reinhart PH. The activation mechanism of rat vanlloid receptor, by capsaicin involves the pore domain and differs from the activation by either acid or heat. Proc Natl Acad Sci USA, 2000, 97: 13889～13894.
6[6]Helliwell RJA, McLatchie LM, Clarke M, et al. Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia. Neurosci Lett, 1998, 250:177～180.
7[7]Cheryl LS, Gary RL. Isolectin B4-positive and negative nociceptors are functionally distinct. J Neurosci, 1999, 19:6405～6497.
8[8]Tominaga M, Caterina MJ, Malmberg AB, et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron, 1998, 21: 531～543.
9[9]Michael GJ, Priestly JV. Differential expression of the mRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. J Neurosci, 1999, 19:1844～1854.
10[10]Ma QP. Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats. Neurosci Lett, 2002, 319: 87～90.
7[1]Cole man RE.Skeletal complications of malignancy[J].Cancer,1997,80:1588-1594
8[2]Thurlimann B,de Stoutoutz ND.Causes and treatment of bone pain of manignant origin[J].Drugs,1996,51:383-398
9[3]Schwei MJ,Honore P,Rogers SD,et al.Neuroche mical and cellular reorganization of the spinal cord in a marine model of bone cancer pain[J].Neurosci,1999,19:10886-10897
10[4]Wacnik PW,Eil meier IJ,Ruggles TR,et al.Functional interaction between tumor and peripheral nerve:morphology,algogen identification,and behavioral characterization of a new marine model of canfer pain[J].Neurosci,2001,21:9355-9366
