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透明质酸酶及其在恶性肿瘤的转移与浸润中的作用 被引量：2

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摘要 透明质酸酶(Hyaluronidase,Hyase)是一种β-1-4内切葡糖胺酸酶,降解透明质酸(Hyaluronan,HA)及其它糖胺聚糖.多年来,由于缺乏简便而敏感的测定方法,Hyase的研究未得到足够的重视,最近随着研究水平的提高,发现Hyase与恶性肿瘤的浸润与转移具有密切关系.本文就Hyase的生化特性及其在恶性肿瘤中的作用作一综述.
作者 汪毅 任国胜
机构地区 重庆医科大学第一附属医院普外科
出处 《实用肿瘤学杂志》 CAS 2005年第2期155-158,共4页 Practical Oncology Journal
基金 国家自然科学基金资助项目(30070292)
关键词 透明质酸酶 恶性肿瘤 浸润 转移 糖胺聚糖 测定方法 研究水平 密切关系 生化特性 葡糖胺 β-1
分类号 R730.2 [医药卫生—肿瘤]
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参考文献23

  • 1Podyma KA, Yamagata S, Sakata K, et al. Difference of hyaluronidase produced by human tumor cell lines with hyaluronidase present in human serum as revealed by zymography [J]. Biochem Biophys Res Commun,1997;241:446～452.
  • 2Mio K, Carrette O, Maibach HI, et al. Evidence that the inhihitor of hyaluronidase may be a member of the inter- α - inhibitor family [J].J Biol Chem, 2000;275:32413～32421.
  • 3Lokeshwar V, Young MJ, Goudarzi G, et al. Identification of bladder tumor- derived hyaluronidase: its similarity to HYAL1 [J]. Cancer Res, 1999;59:4464～4470.
  • 4Pham HT, Block NL, Lokeshwar VB. Tumor- derived hyaluronidase:a diagnostic urine marker for high - grade bladder cancer [J]. Cancer Res, 1997;57:778～783.
  • 5Menzel EJ, Farr C. Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses [J]. Cancer lett,1998;131:3～11.
  • 6Frost GI, Csoka TB, WongT, etal. Purification, cloning, and expression of human plasma hyaluronodase [J]. Biochem Biophys Res Commun, 1997;236:10～15.
  • 7Natowicz MR, Short MP, Wang Y, et al. Clinical and biochemical manifestations of hyaluronidase deficiency [J]. N Engl J Med, 1996;335:1029～1033.
  • 8Cs o ka AB, SchererSW, Stem R. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31 [J]. Genomics 1999;60:356～361.
  • 9Liu DC, Pearlman EP, Diaconu E, et al. Expression of hyaluronidase by tumor cells induces angiogenesis in vivo [J]. Proc Natl Acad Sci USA, 1996;93:7832～7837.
  • 10Tamakoshi K, Kikkava F, Maeda O, etal. Hyaluronidase activity in gynaecological cancer tissues with different metastatic forms [J]. Bri J Cancer, 1997;75:1807～1811.

同被引文献14

  • 1王丽辉,刘大渔,吕申.乳腺癌的淋巴道转移与癌细胞中MMP-9表达的相关性[J].大连医科大学学报,2001,23(4):264-266. 被引量：1
  • 2Bertrand D,Philippe D,Catherine M,et al.Enzyme-linked hyaluronection:a unique reagent for hyaluronan assay and tissue location and for hyaluronidase activity detection.Anal Biochem,1995,229:35-41.
  • 3Lokeshwar VB,Lokeshwar BL,Pham HT,et al.Association of elevated levels of hyaluronidase,a matrix-degrading enzyme,with prostate cancer progression.Cancer Res,1995,56:651-657.
  • 4Lokeshwar VB,Obek C,Pham HT,et al.Urinary hyaluronic acid and hyaluron-idase:markers for bladder cancer detection and evaluation of grade.J Urol,2000,163:348-356.
  • 5Hautmann S,Toma M,Lorenzo-Gomez MF,et al.Immunocyt and the HA-HAase urine tests for the detection of bladder cancer:a side-by-side comparison.Eur Urol,2004,46(4):466-471.
  • 6Bertrand P,Girard N,Duval C,et al.Increased hyaluronidase levels in breast tumor metastases.Int J Cancer,1997,73:327-331.
  • 7Victor R,Chauzy C,Girard N,et al.Human breast-cancer metastasis formation in a nude-mouse model:studies of hyaluronidase,hyaluronan and hyaluronan-binding sites in metastatic cells.Int J Cancer,1999,82:77-83.
  • 8Torii A,Kodera Y,Uesaka K,et al.Plasma concentration of matrix metalloproteinase-9 in gastic cancer.Br J Surg,1997,84:133-136.
  • 9杨中民,周智华,孔令臣,孙少晨,郭立军,张金丽,曹大福.明胶/透明质酸复合支架材料的制备及性能[J].粉末冶金材料科学与工程,2012,17(6):810-817. 被引量：5
  • 10张堃,简军,张政朴.透明质酸的结构、性能、改性和应用研究进展[J].高分子通报,2015(9):217-226. 被引量：31

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实用肿瘤学杂志
2005年 第2期

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