期刊文献+

双特异性单克隆抗体在肿瘤治疗中的应用

Recent advances and applications of bispecific monoclonal antibodies in cancer therapy
下载PDF
导出
摘要 双特异性单克隆抗体(BsMAb)是含有两个不同配体结合位点的免疫球蛋白分子,在疾病的诊断治疗上具有较大临床应用潜力,特别在肿瘤治疗方面,有其不容忽视的优越性。现综述近年来BsMAb在肿瘤治疗中的研究及应用进展。同时,对其人源化进程也进行了概述。
出处 《国外医学(肿瘤学分册)》 2005年第4期270-273,共4页 Foreign Medical Sciences (Cancer Section)
  • 相关文献

参考文献23

  • 1Withoff S, Helfrich W. Bi-specific antibody therapy for the treatment of cancer. Curr Opin Mol Ther,2001,3( 1 ) :53-62.
  • 2Talac R, Nelson H. Current perpectives of bispecific antibody-based immunotherapy. J Biol Regul Homeost Agents, 2000, 14 ( 3 ): 175-181.
  • 3Cao Y, Lam L. Bispecific antibody conjugates in therapeutics. Adv Drug Deliv Rev,2003,55(2) :171-197.
  • 4Annemiek B, Hwidi H, Jan GJ. Immunotherapeutic perspective for bispecific antibodies. Immunology Today,2000,21 (8) :391-397.
  • 5Chambers CA, Allison JP. Costimulatory regulation of T-cell function. Curr Opin Cell Biol, 1999,11 (2) :203-210.
  • 6Keler T, Wallace PK, Vitale LA, et al. Differential effect of cytokine treatment on FcαR Ⅰ and FcγR Ⅰ mediated tumorcytotoxicity by mionocyte. J Immunol,2000,164( 11 ) :5746-5752.
  • 7Hartmann F, Renner C, Jung W,et al. Anti-CD16/CD30 bispecific antibody treatment for Hodgkin's disease:role of infusion schedule and costimulation with cytokines. Clin Cancer Res, 2001,7 ( 7 ): 1873-1881.
  • 8Borchmann P, Schnell R, Fuss, et al. Phase Ⅰ trial of the novel bispecific molecule H22 × Ki-4 in patients with refractory Hodgkin lymphoma. Blood,2002,100(9) :3101-3107.
  • 9Ford CH,Osborne PA, Rego BG, et al. Bispecific antibody targeting of doxorubicin to carcinoembryonic antigen-expressing colon cancer cell lines in vitro and in vivo. Int J Cancer,2001,92(6) :851-855.
  • 10Bagshawe KD,Sharma SK, Burke,PJ, et al. Developments with targeted enzymes in cancer therapy. Curr Opin Immunol, 1999,11 ( 5 ):579-583.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部