西沙必利在腹膜氧合治疗急性肺损伤中对循环和呼吸的影响

The Effect on Circulation and Respiration of Peritoneal Oxygenation in Treating Acute Lung Injury with Cisapride

目的:探讨西沙必利在腹膜氧合治疗急性肺损伤中对循环和呼吸的影响。方法:24 只家兔经油酸诱发急性肺损伤模型后,随机分为3组,每组8只,分别为腹膜氧合组(A组)、腹膜氧合西沙必利组(B组)、非腹膜氧合西沙必利组(C组)。观察每组在急性肺损伤出现后1 h、2 h、4 h心率、平均动脉压、呼吸次数的变化。结果:A、B组在氧合后平均动脉压有显著改善(P<0.05),C组则改善不明显(P>0.05);3 组间呼吸次数的变化无统计学意义(P>0.05)。结论:在腹膜氧合治疗急性肺损伤过程中,西沙必利对循环和呼吸没有显著影响。

Objective:To explore the effect of peritoneal oxygenation on circulation and respiration in treating acute lung injury with cisapride.Methods:After acute lung injury was induced in adult rabbit with oleic acid,twenty-four rabbits were randomly divided into three groups(n=8,each) and received:peritoneal oxygenation without cisapride group(group A);peritoneal oxygenation with cisapride group(group B)and non-peritoneal oxygenation with cisapride group(group C).The changes of heart rate(HR) and mean artery pressure(MAP)were observed after acute lung injury was induced and treatment was commenced at 1,2,4 hours.Results:MAP were no obviously change in group C,meanwhile were gradually increased in group A and group B(P<0.05).Respiration was no change in each other group.Conclusion:There was no change on circulation and respiration in treating acute lung injury with cisapride.