严重烧伤患者外周血T细胞亚群NK细胞与血清sIL-2R的相关性研究

Study on the Correlation between the T Lymphocyte Subsets,NK Cell in Peripheral Blood and the Level of Serum sIL-2R of Patients with Severly Burned

目的:观察严重烧伤患者外周血T细胞亚群,NK细胞活性及血清sIL -2R的表达,探讨两者的相关性。方法:检测35例严重烧伤患者(烧伤组)的各细胞免疫指标,并与10例健康献血员(对照组)进行对比。结果:①严重烧伤患者较对照组CD3+、CD4+、NK活性CD4+/CD8+比值明显下降,同时伴有CD8+ 增高;②严重烧伤患者血清sIL -2R表达显著高于对照组;③CD3+、CD4+、NK活性CD4+/CD8+比值与血清sIL -2R表达呈负相关;而与CD8+无明显相关性。结论: 严重烧伤患者细胞免疫受到抑制,并与sIL- 2R有良好的相关性。

Objective:To probe the correlation between the T lymphocyte subsets,NK cells in peripheral blood and the level of serum sIL-2R of patients with severely burned.Methods:The T lymphocyte subsets,NK cells in peripheral blood and the level of serum sIL-2R of 35 patients with severly burned and healthy controls were tested.Results:①The CD 3+、CD 4+T lymphocytes and CD 4+/CD 8+ rotio NK in the peripheral blood of patients with severly burned were lower than that of the healthy and the CD 8+ T lymphocytes were higher than that of the healthy controls signifcantly;②The levels of serum sIL-2R were higher than that of the healthy controls significantly;③The CD 3+、CD 4+、NKcells,CD 4+/CD 8+ ratio were in negative relationship with the serm sIL-2R level.Conclusion:The cellular immune function of patients with severly burned was lower than that of the healthy controls and the T lymphocyte subsets in peripheral blood has significant relation to the level of serum sIL-2R.