摘要
目的:研究基质金属蛋白酶- 9(MMP - 9)的表达与甲状腺癌的临床分期和淋巴结转移的关系,探讨其在甲状腺癌发生发展、侵袭和转移中的机制。方法:采用免疫组织化学SP法检测5 0例甲状腺癌标本及2 0例癌旁正常甲状腺组织中MMP - 9蛋白的表达。结果:甲状腺癌中MMP - 9的表达显著高于癌旁正常组织,与甲状腺癌的临床分期和淋巴结转移密切相关。结论:MMP - 9在甲状腺癌的侵袭转移中发挥关键作用。
Objective: To investigate the correlation between the expression of MMP-9 and histological feature,clinical stage, lymph node metastasis in thyroid carcinoma. Methods: The SP immunohistochemical method was employed to determine the expression of MMP-9 in 50 cases of thyroid carcinoma and 20 cases of para-tumorous tissue. Results: The expression of MMP-9 in thyroid carcinoma was remarkablely higher than that in the para-tumorous tissue,the result was uncorrelated with histological feature,but correlated with clinical stage and lymph node metastasis.Conclusions: The expression of MMP-9 is associated with invasion and metastasis of thyroid carcinoma,which may serve as prognosis indexes of thyroid carcinoma.
出处
《医学理论与实践》
2005年第4期389-390,共2页
The Journal of Medical Theory and Practice
