急性白血病化疗后医院感染及抗感染治疗分析

Hospital Infection after Chemotherapy in Acute Leucemia Patients and Its Anti-infection Therapy

目的 探讨急性白血病(AL)化疗后医院感染(HAI)的易感因素、防治方法及预防措施。方法 对83 例初治急性白血病住院化疗后的医院感染发生及治疗情况进行回顾性分析。结果 中性粒细胞计数(ANC)减低、年龄>60岁患者医院感染率增高;抗生素联合粒细胞集落刺激因子(G-CSF)治疗使化疗后AL患者发热及ANC恢复天数分别缩短为(7. 0±1. 8)d和(9.8±2.0)d。结论 急性白血病患者化疗后ANC和患者年龄是医院感染主要易感因素,抗生素加用G-CSF能减少医院感染发生率及严重程度。

OBJECTIVE To investigate the factors of hospital infection after chemotherapy in acute leucemia patients, and discuss the methods of preventing and curing. METHODS Eighty three hospital infection cases and their therapy were analyzed retrospectively in acute leucemia patients who had been accepted primary chemotherapy. RESULTS The infection rate of the patients whose age exceeded 60 and the absolute neutrophil count(ANC) depressed were heightened. The method of G-CSF adding antibiotic shortened the days of fever and ANC reversion as 7.0±1.8, 9.8±2.0, respectively. CONCLUSIONS The low level of ANC and the old ages are the primary factors that lead to hospital infection; the method of G-CSF adding antibiotic could reduce the hospital infection rate and its seriousness.