Ⅱ型糖尿病患者血清糖基化胰岛素水平及与胰岛素抵抗的关系

Serum Glycosylated Insulin Level in Type Ⅱ Diabetics and its Relationship with Insulin Resistance

３３例Ⅱ型糖尿病患者行葡萄糖耐量试验和胰岛素释放试验。利用胰岛素抗体分离血清胰岛素，比色法测定血精糖基化胰岛素水平。糖尿病患者血清糖基化胰岛素水平显著升高，且与血糖水平呈显著正相关，与胰岛素抵抗的有关指标呈显著负相关，提示血清糖基化胰岛素水平取决于血糖水平，且可能与胰岛素抵抗的形成有关。

g oral glucose tolerant test and insulin releasing test were performed in 33 patients with type Ⅱ diabetes mellitus.Glycosylated insulin(GI)was determinated with nitroblue tetrazolium(NBT)colorreaction using anti-insulin antibody for precipitation of serum insulin.GI level was increased significantly in diabetics and correlated positive with fasting blood glucose concentration, negative with the ratio of fasting serum insulin/glucose concentration and the ratio of the area under the insulin curve over the area under the glucose curve. The results indicate that GI level depends on the condition of the blood glucose control and is involved in the development of insulin resistance.