克山病病区粮饲养豚鼠的冠状动脉反应性的研究

Coronary artery reactivity of guinea pig fed with grain from Keshan disease area

克山病以围血管的心肌坏死灶为其特征，本文研究了血管因素在其发病中的作用。所用动物模型是用豚鼠饲以克山病病区粮建立的。冠状动物的反应性的研究采用测定血管条单位平方面定积实际收缩张力的方法（ｍｇ／ｍｍ￣２）。结果：（１）Ｓｅ对模型动物冠脉平滑肌的舒张作用明显减弱，使其剂量—反应曲线右移，表明钙通道活动的加强。（２）在动物模型，激动剂ＫＣｌ及Ａｃｈ产生的实际收缩张力显著增强，表明此时冠状动脉平滑肌反应性增加。根据上述结果，我们认为冠状动脉反应性增强，即血管因素在克山病的发病学中占据重要位置。

Perivascular necrosis of cardiac muscle fiber was characteristics of Keshan disease.This work reported the vascular role in the pathogenesis of necrosis. Guinea pig fed with grain from Keshan disease area was used as animal model.The coronary artery reactivity were examined by measurement of active isometric force developed by vascular segment ( mg/mm￣2).The results were as follows:1.Relaxationcoronary artery smooth muscle by Se was reduced significantly which was indicated by the shift of dose response curve to the right.This suggested that calcium channel activity might be increased,2.the active tension of coroary artery smooth muscle induced by KCl and ACh increased ob-viously.It was shown that the reactivity of coronary arterialsmooth muscle augmented.These results suggested that increase of coronaryarteryresponsiveness played an important role in the pathogenesis of Keshandiseases.