548例自发流产妇女及其中500例配偶的染色体分析

Analysis of chromosome abnormalities in 548 women with history of spontaneous abortion and their spouse in 500 cases

目的:从遗传与优生学角度探讨对自发流产妇女及其配偶进行染色体检测的意义。方法:对548例自发流产妇女及其中500例配偶的染色体进行核型分析。结果:1048例中发现25例染色体异常,其中平衡易位携带者10例、性染色体数目异常4例、其他结构异常11例。结论:配偶中一方染色体异常可导致自发流产,自发流产与遗传因素密切相关。

Objective:To investigate the relationship between recurrent spontaneous abortion and abnormalities of chromosome.Methods:A total of 548 women with history of spontaneous abortion enrolled in the detection of chromosome as well as their spouse in 500 cases.Results:25 cases had abnormalities of chromosome,including 10 balanced translocation,4 sexual chromosome number abnormalites and 11 structural aberration.Comparison of these abnormalities to the obstetrical history were carried out in these pregnant women.Conclusion:Genetic factors play an important role in spontaneous abortion and marked influence on the eugenics.