Graves病手术前后血清甲状腺刺激免疫球蛋白的检测

Assay of serum thyroid stimulating immunoglobing of patients with Graves disease after partial thyroidectomy

本文用细胞化学法进行甲状腺刺激免疫球蛋白（ＴＳＩ）的测定。将４３例受试者分为正常对照组（１５例）和甲亢组（２８例），甲亢组中的１５例于手术前后分别测定ＴＳＩ，阳性率：正常组２０％；甲亢组５３．６％；１５例手术病人术前５３．３％、术后６．７％。作者认为：ＧＤ患者体内存在ＴＳＩ，支持ＴＳＩ是ＧＤ甲亢发病的主要因素的主张。大多数经过内科治疗甲亢症状未控制的ＧＤ患者，血清ＴＳＩ可被检出，经过手术治疗的ＧＤ患者，血清ＴＳＩ阳性率明显降低，手术可以通过减少ＴＳ的生成而达到治疗甲亢的目的。长期药物治疗症状未获控制、ＴＳＩ持续阳性的患者应考虑手术治疗。

TSI was measured by cytochemical assay. In normal subjects, three(20%)had detectable serum-TSI, while in Graves disease patient 15(53.6%)were detectable.Before partial thyroidectomy eight out of fifteen patients(53.3%)detected TSI in theserum. After the operation, only one out of fifteen(6.7%)detected TSI.