丹参对大鼠胃泌素所致胃液分泌、胃体、十二指肠粘膜血流和胃窦运动的影响

The effect of Danshen on tetragastrin-stimulated gastric acid secretion and mucosal blood flow and antral motility in rat

本文采用幽门结扎法，氢气清除和应力感受器技术分别测量了丹参注射前后胃液分泌量，胃体十二指肠粘膜血流量和胃窦运动的改变，以进一步探讨丹参的抗消化性溃疡作用机理。结果表明，丹参灌注后４０分钟左右，胃泌素所致的胃液分泌亢进和胃酸排出增多受到明显抑制；丹参注入后２０分钟，胃体和十二指肠粘腹的血流量分别增加了２５．３％和２８．３％（Ｐ＜０．０１）；丹参对胃窦运动的收缩频率无影响，但却抑制其收缩振幅，注入丹参后１０、３０和６０分钟，胃窦运动指数分别下降了１４．９６％、１６．２６％和１４．９０％（Ｐ＜０．０５）。上述结果提示，改善粘膜血流供应，降低胃窦运动是丹参抗消化性溃疡的主要作用机制。

The anti-ulcer effect of Danshen was studies by investigating gastric acid secretion,mucosal blood flow and antral motility with Pylorus ligation method,hydrogengas clearence and force transducer techniques was used.The results were as follows:thegastric volume,hypersecretion,and total acidity enhancement induced by tetragastrin werein hibited by Danshen perfusion for 40-min;The mucosal blood flow of gastric corpus andduodenum at 20-min of Danshen injection was decreased 25.3%and 28.3%(P<0.01)respectively compared with those of control group.The antral motility frequency was notchanged by Danshen ,but its amplitude decreased significantly.The antral motility indexdroped 14.96%,16.26%and 1 4.90%respectively at 10,30,60min after Danshen injec-tion.This suggested that the anti-ulcer effect of Danshen was closely related to it's impro-vement of mucosal blood flow and its inhibition of antral motility.