黑色素细胞刺激素对家兔血细胞生成内生致热原的影响

The effect of α-melanocyte-stimulating hormone on the production of endogenous pyrogen in rabbit’S blood cells

本文观察了黑色素细胞刺激素（α－ｍｅｌａｎｏｃｙｔｅ－ｓｔｉｍｕｌａｔｉｎｇｈｏｒｍｏｎｅ，α－ＭＳＨ）对体外培育的兔全血细胞产生内生致热原（ｅｎｄｏｇｅｎｏｕｓｐｙｒｏｇｅｎ，ＥＰ）的影响。结果显示，Ⅲ组（“α－ＭＳＨ＋ＥＴ＋全血培养物”上清）的致热性明显低于Ⅱ组（“ＥＴ＋全血细胞培养物”上清）（０．０１＜Ｐ＜０．０５）；而α－ＭＳＨ单独与血细胞培养无降温物质产生；同时，相同剂量的α－ＭＳＨ对ＥＰ性发热无直接抑制作用。由此作者推论，α－ＭＳＨ能抑制ＥＴ诱生ＥＰ的产生，而这一作用可能是其抑制ＥＴ性发热的主要机制之一。

The experiment was carried out to study the effect of α-MSH on the pro-duction of EP in cultured blood cells.It was found that group Ⅲ(α-MSH culturedwith ET+blood cells)resulted in a marked attenuation of fever magnitude compared withthat of the group Ⅱ(ET cultured with blood cells)(0.01<P<0.05),But the same dosageof α-MSH had no effect on EP-induced fever and not any cryogen could be found whileonly α-MSH was cultured with blood cells.These results indicated that the inhibitoryeffect of α-MSH on the production of EP might be one of the mechanisms of loweringET-induced fever.