精氨酸加压素对家兔血细胞生成内生致热原的影响

The effect of arginine vasopressin on the production of endogenous pyrogen in rabbit’s blood cells

本文观察了精氨酸加压素（ａｒｇｉｎｉｎｅｖａｓｏｐｒｅｓｓｉｎ，ＡＶＰ）对体外培育的兔全血细胞产生内生致热原（ｅｎｄｏｇｅｎｏｕｓｐｙｒｏｇｅｎ，ＥＰ）的影响。结果表明，ＡＶＰ对内毒素（ｅｎｄｏｔｏｘｉｎ，ＥＴ）诱生ＥＰ过程有明显抑制作用；而ＡＶＰ单独与血细胞培养无降温物质产生；同时，所用剂量的ＡＶＰ对ＥＰ性发热无直接抑制作用。因此作者认为，ＡＶＰ能够抑制ＥＴ诱生家兔血细胞生成ＥＰ，这可能是其降低或阻断ＥＴ性发热的主要机制之一。

The effect of AVP on the production of EP in cultured blood cells wasstudied.The results showed that AVP could markedly inhibit the production of ET-indu-ced EP,while it (in the same dosage)had no effect on the Ep-induced fever and not anycryogen could be found when only AVP was cultured with blood cells.In accordancewith these findings,the authors suggested that one of the mechanisms of the effect oflowering ET-induced fever by AVP might be the fact that it inhibited the production of EP.