摘要
本文观察了精氨酸加压素(argininevasopressin,AVP)对体外培育的兔全血细胞产生内生致热原(endogenouspyrogen,EP)的影响。结果表明,AVP对内毒素(endotoxin,ET)诱生EP过程有明显抑制作用;而AVP单独与血细胞培养无降温物质产生;同时,所用剂量的AVP对EP性发热无直接抑制作用。因此作者认为,AVP能够抑制ET诱生家兔血细胞生成EP,这可能是其降低或阻断ET性发热的主要机制之一。
The effect of AVP on the production of EP in cultured blood cells wasstudied.The results showed that AVP could markedly inhibit the production of ET-indu-ced EP,while it (in the same dosage)had no effect on the Ep-induced fever and not anycryogen could be found when only AVP was cultured with blood cells.In accordancewith these findings,the authors suggested that one of the mechanisms of the effect oflowering ET-induced fever by AVP might be the fact that it inhibited the production of EP.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1994年第4期358-361,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
广东省科学基金