Ⅱ型糖尿病患者红细胞膜MDA与膜钠泵K^＋—pNPPase活性的关系

Relationship between erythrocyte membrane MDA and Na￣+-pumping K￣+-activated pNPPase in NIDDM

本文测定５５例ＮＩＤＤＭ患者血浆及红细胞膜ＭＤＡ水平和钠泵Ｋ＋－ｐＮＰＰａｓｅ活性。结果显示，ＮＩＤＤＭ患者血浆和红细胞膜ＭＤＡ水平明显高于正常对照组，钠泵Ｋ＋－ｐＮＰＰａｓｅ活性明显低于对照，在伴有视网膜病变者上述改变更为显著，红细胞膜ＭＤＡ升高和钠泵Ｋ＋－ｐＮＰＰａｓｅ活性降低呈明显负相关。提示红细胞膜ＭＤＡ升高可能是导致Ｋ＋－ｐＮＰＰａｓｅ活性降低的一重要因素。

The malondialdehyde(MDA) levels in plsama and erythrocyte membrane,activity of erythrocyte membrane Na￣-pumping K￣+-activated paranitrophenylphosphatase (pNPPase) were studied in 55 adult with non-insulin-dependent diabetes mellitus (NIDDM).The plasma and erythrocyte MDA levels were increased very much in comparison with the healthy subject,while erythrocyte membrane Na￣+-pumping K￣+-activated pNPPase activity were decrcased.The changes of lipid peroxide and enzyme activity were more severe in NIDDM with retinopathy than those without.The rises of MDA and the descend of Na￣+pumping K￣+-activated pNPPase were closely negative related in NIDDM subjeet.This indicated that the rises of erythrocyte membrane MDA may be the main reason for decreased Na￣+pumping K￣+-activated pNPPase activity in NIDDM.