肝移植术后胆道感染患者的革兰氏阴性细菌耐药性监测

The antibiotic resistance of biliary Gram-negative bacteria infections in liver transplantation patients

目的:探讨从肝移植术后胆道感染患者分离的革兰氏阴性细菌的分布及耐药性。方法:对235例肝移植术后有胆道感染的患者的胆汁行细菌培养,统计其革兰氏阴性细菌的检测结果及药敏结果。结果:胆汁标本中共分离出病原菌537株,其中革兰氏阴性细菌431株,占80.3%。革兰氏阴性细菌中前6位细菌依次是大肠埃希氏菌、铜绿假单胞菌、肺炎克雷伯菌、鲍曼不动杆菌、嗜麦芽窄食单胞菌、阴沟肠杆菌,对绝大多数抗生素耐药。结论:肝移植术后患者胆道感染的病原菌以革兰氏阴性细菌为主,实验室通过对病原菌及其耐药性检测,指导临床合理使用抗生素对降低肝移植患者术后感染非常重要。

Objective: To investigate the distribution and antibiotic resistance of biliary Gram-negative bacteria infections in liver transplantation patients. Methods: Biliary specimens from 235 liver transplant patients with biliary Gram-negative bacteria infections were cultured for bacterial identification and the drug-sensitivity results. Results: A total of 537 strains,80.3% of which were Gram-negative bacteria.The most common pathogens of them were Escherichia coil?Pseudomonas aeruginosa?Klebsiella pneumoniae?Acinetobacter baumannii?Pseudomonas maltophilia and Enterobacter cloacae,and most were drug-resistant. Conclusion: The main pathogenic microbes of biliary infection were Gram-negative bacteria in liver transplantation patients,strengthening the supervision of the resistance of bacteria and using antibiotics correctly were very important to decreasing the infections after the liver transplantation.