红外光谱法测试高温融熔工艺对甲氨蝶呤植入剂结构的影响

Determination of the structural change of methotrexate as an implant under the high-temperature fusion by infrared spectroscopy

目的:观测甲氨蝶呤植入剂的高温融熔生产工艺对药物结构的影响。方法:测试该植入剂及各配方成分的红外光谱图,再以标准谱图比对,检查因结构变化而形成的吸收峰变化。结果:该植入剂图谱中,各配方成分的特征峰呈叠加状态,不多一峰,不少一峰。结论:该植入剂中药物结构未出现明显变化。

Objective: To determine by IR whether the high-temperature fusion makes an impact on methotrexate structure. Methods: Comparison of the IR spectrum for the different formulae containing methotrexate to the standard IR spectrum was conducted. Results: All spectral characteristics between each formula showed no changes. Conclusion: The high-temperature fusion has few impacts on methotrexate structure.