马兜铃酸毒理学性研究与启示

Implication of aristolochic acid safety

有关马兜铃酸的毒理实验国内外均有报道,尤其国外在毒理学方面做了大量研究。大量的实验提示:马兜铃酸的肾毒性与剂量呈相关性;遗传毒性研究提示马兜铃酸具有致突变作用;在对大鼠和小鼠的长期毒性研究中发现:动物可发生局部和全身肿瘤,且肿瘤的发生与给药时间和剂量呈相关性;并发现动物的主要毒性与人的不良反应有相关性。马兜铃酸的相关实验研究提醒有关方面应重视马兜铃酸问题,使传统中药更好地发挥防病治病作用。

There have been numerous domestic and international reports of nephrotoxicity associated with botanical products found to contain aristolochic acid. Many investigations disclosed cases of nephropathy and end-stage renal diseases associated with ingestion of products containing aristolochic acid. Of further concern is carcinogenic potential of aristolochic acid. Aristolochic acid, when tested for carcinogenicity by oral administration in mice and rats,induced chronically toxicity,and led to local and systemic tumors. Furthermore,patients taking aristolochic acid may be at increased risk of developing malignancies. The toxic effects of aristolochic acid in animals have been inferred from effects seen in patients suffering from kidney nephropathy as a result of consuming herbal mixtures containing aristolochic acid. Concerns about botanical-containing products known or suspected of containing aristolochic acid will bring to our attention important safety information relative to nephrotoxicity associated with aristolochic acid and rationality to utilize traditional Chinese medicine.