肺炎衣原体感染与呼吸系统疾病的血清学相关性研究

The study on the serological association between Chlamydia pneumoniae infection and some respiratory diseases

目的 探讨肺炎衣原体 (Chlamydia Pneumoniae,CPn)感染与呼吸系统常见疾病的相关性。方法 采用间接免疫荧光法检测 CPn特异性抗体 Ig A、Ig G、Ig M。结果 肺癌组、慢性阻塞性肺疾病 (COPD)组和支气管哮喘组的既往感染率与慢性感染率明显高于自发性气胸组和健康献血员对照组 (P<0 .0 5 ) ;而肺癌组、COPD组和支气管哮喘组之间以及自发性气胸组和健康献血员对照组之间的感染率则无统计学意义 (P>0 .0 5 )。结论 CPn血清特异性抗体 Ig A、Ig G的升高与肺癌、COPD和支气管哮喘相关 ,CPn感染可能参与了其发病机制。

Objective To investigate the serological association between chlamydia pneumoniae(CPn)infection and some kinds of respiratory diseases such as lung cancer,chronic obstructive pulmonary disease(COPD),bronchial asthma,and so on.Methods Cpn-specific serum IgA,IgG,IgM antibodies were measured by indirect-immunofluorescence test. Results The prevalence of past and chronic CPn infection in patients with lung cancer,COPD and bronchial asthma was higher than that in the healthy bolld donors and spontaneous pneumothorax(P<0.05).There were no statistical difference among lung cancer,COPD and bronchial asthma groups.The statistical difference was not found between healthy blood donors and spontaneous pneumothorax groups(P>0.05).Conclusion There was suggestive evidence of a stronger association between the specific serum IgA,IgG and lung cancer,COPD,bronchial asthma at CPn infection.The chronic infection may be involved in the pathogenesis of such diseases.