母牛分枝杆菌菌苗治疗菌阳肺结核的疗效评价

Effect and evaluation of postitive bacteria pulmonary tuberculosis treated with chemotherapy and Mycobacterium vaccae vaccine

目的 评价化疗并用母牛分枝杆菌菌苗 (微卡菌苗 )治疗菌阳肺结核的疗效。方法 将 191例初、复治菌阳肺结核患者随机分为 A、B、C、D组 ,A、C组 (各 5 0例 )分别采用 2 HRZS/ 4 HR和 2 HRZES/ 6 HRE加微卡菌苗方案治疗 ;B组 (46例 )、D组 (45例 )单纯用 2 HRZS/ 4 HR和 2 HRZES/ 6 HRE方案治疗。观察治疗后肺部病灶吸收、痰菌阴转情况。结果 第 2月末痰菌阴转率 :A、B组分别为 96 .0 %和 78.3% ;C、D组分别为 92 .0 %和 6 8.9% ;疗程结束痰菌阴转率 A、B组分别为 98.0 %和 87.0 % ;C、D组 96 .0 %和 77.8%。疗程结束胸片改善有效率 A、B组96 .0 %和 84 .8% ;C、D组 92 .0 %和 73.3%。空洞闭合 A、B、C、D组分别为 83.33%、5 2 .6 3%、78.5 7%、4 5 .0 0 %。结论 微卡菌苗能提高痰菌阴转率 ,促进病灶吸收 ,是一种较好的免疫制剂。

Objective To observe and evaluate the curative effect of postitive bacteria pulmonary tuberculosis treated with chemotherapy and Mycobacterium vaccae vaccine.Methods 191 primary and re-treated positive bacteria pulmonary tuberculosis cases were separated into group A,B,C,D at random.Group A(50 cases) and group C(50 cases )were treated with 2HRZS/4HR and 2HRZES/6HRE plus Mycobacterium vaccae vaccine .Group B(46 cases )and group D(45 cases)treated with 2HRZS/4HR and 2HRZES/6HRE alone.Then observe the foci absorption and the sputum negative conversion. Results At the end of 2 months ,the sputum negative conversion rate to group A,B,C,D was separately 96.0%,78.3%,92.0% and 68.9%.At the end of treatment,the sputum negative conversion rate to group A,B,C,D was separately 98.00%,87.00%,96.00% and 77.8%;the foci absorpation rate to group A,B,C,D was separately 96.00%,84.80%,92.00% and 73.3%;cavity close up was separately 83.33%,52.63%,78.57% and 45.00%.Conclusion Mycobacterium vaccae vaccine can improve the sputum negative conversion rate,accelerate the foci absorption.It is a better immunity injection.