高血压病合并糖尿病患者尿微量蛋白与左室重量指数的关系和意义

The relationship between microalbuminuria and left ventricular mass index in hypertensive patients with type II diabetes

目的探讨高血压病合并糖尿病患者尿微量蛋白、左室重量指数(LVMI)的变化及其相互关系。方法采用免疫发光法测定36例高血压病患者(EH组)、35例糖尿病患者(DM组)和34例高血压病合并糖尿病患者(EM+DM组)的尿微量蛋白,并对3组患者作超声心动图检查,根据有关数据计算出LVMI,并对结果进行比较分析。结果3组尿微量蛋白各项指标均高于正常范围,EH+DM组尿微量白蛋白(ALB)、LVMI较EH组、DM组显著升高(均P<0.05)。LVMI与ALB、尿转铁蛋白、免疫球蛋白均呈显著正相关(均P<0.05)。结论高血压病和糖尿病可引起尿微量蛋白的增高,并且与LVMI相关,两者并存可以加重心、肾等脏器的损害。

Objective To investigate the relationship of microalbuminuria and left ventricular mass index (LVMI) in hypertensive patients with type II diabetes. Methods One hundred and five subjects were divided into 3 groups: hypertensive patients (H group, n=36), type II diabetes patients (D group n=35) and hypertensive patients with type II diabetes (H+D group, n=34). The microalbuminuria was measured by immunochemiluminometric assay. The LVMI was calculated based ultrasonic cardiography (UCG). Results The microalbuminuria levels in all three groups were higher than the normal level. There were significantly differences in microalbuminuria levels and the LVMI between H+D and H groups and between H+D and D groups (both P<0.05). LVMI was positively related to the microalbuminuria, transferrin (TRF) and immunoglobulin (IgG) levels (P<0.05). Conclusion The microalbuminuria level in hypertension and diabetes patients increases and it is correlated with the LVMI. The coexisting of the microalbuminuria and the LVMI might aggravate the pathological changes.