抗精子抗体与抗子宫内膜抗体在女性不孕中的检测价值

Detective value of antisperm antibody and antiendometrial antibody in female infertility

目的:研究抗精子抗体(AsAb) 与抗子宫内膜抗体(EmAb) 的检测对女性不孕(育) 症的应用价值, 为临床提供可靠诊断及治疗依据。方法: 应用酶联免疫吸附试验(ELISA法) 对656例不孕妇女进行了抗精子抗体与抗子宫内膜抗体检测, 同时与健康孕妇作对比研究。结果: 全组女性不孕病例检测AsAb总阳性占40 .24% ( 264 /656 ), 其中血清阳性率16. 62 (109 /656), 健康孕妇血清AsAb阳性率则为4. 35 (2 /46), 经统计学处理, χ2 =3 .89, P<0 .05; 而原发不孕占39. 60%(177 /447), 继发不孕占41. 63% (87 /209)。EmAb检测不孕组为33. 54% ( 220 /656 ), 健康孕妇组为4 35% ( 2 /46 ), 两组对比P<0 .01。结论: AsAb和EmAb的检测对女性不孕(育) 症的诊断和预后具有极其重要的价值。

Objective:By exploring the detective value of antisperm antibody (AsAb) and antiendometrial antibody (EmAb) in female infertility to supply the reliable basis for diagnosis and treatment.Methods:AsAb and EmAb of 656 females with infertility were determined by ELISA and compared to those of normal controls.Results:Total positive rate of AsAb in female infertility group accounted for 40.24% (264/656), serum positive rate 16.62% (109/656), that of normal was 4.35% (2/46) ( χ 2 =3.89, P <0.05), that of primary infertility 39.60% (177/447), that of secondary infertility 41.63% (87/209). EmAb in female infertility group accounted for 33.54% (220/656), that of controls 4.35% (2/46) ( P <0.01). Conclusion:Detection of AsAb and EmAb should play an important role in diagnosis and prognosis of female infertility.