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先兆子痫患者血清胰岛素样生长因子-Ⅱ的检测意义 被引量：1

The significance of detection of serum insulin-like growth factor-Ⅱin patients with preeclampsia
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摘要 目的:探讨胰岛素样生长因子-Ⅱ(IGF-Ⅱ) 在先兆子痫发病机制中的作用。方法: 用ELISA方法测定88例先兆子痫和21例正常晚孕妇女血清IGF-Ⅱ的水平。88例先兆子痫患者中15例为轻度先兆子痫, 73例为重度先兆子痫, 统计学方法采用t检验。结果: 重度先兆子痫组IGF-Ⅱ显著高于正常晚孕组(P<0 05) 和轻度先兆子痫组(P<0 05)。结论:先兆子痫患者血清IGF-Ⅱ显著升高, 且随病情加重明显升高, IGF-Ⅱ可能是先兆子痫病理过程中主要调节因子之一。 Objective:To explore the role of serum insulin-like growth factor-Ⅱ(IGF-Ⅱ) in the mechanism of preeclampsia.Methods:Serum IGF-Ⅱlevels in 88 pregnant women with preeclampsia (15 cases with mild preeclampsia, 73 cases with severe preeclampsia) and 21 normal pregnant women were determined by ELISA.Results:Serum IGF-Ⅱlevels in severe preeclampsia group were significantly higher than that in normal controls and mild preeclampsia group (both P <0.05). Conclusion:Serum IGF-Ⅱlevels in patients with preeclampsia significantly increased with severity of diseases, which could be one of main regulative factors in course of preeclampsia pathogenesis.
作者 常彩红 张展 贾莉婷
机构地区 郑州大学第三附属医院
出处 《中国妇幼保健》 CAS 北大核心 2005年第8期955-956,共2页 Maternal and Child Health Care of China
关键词 先兆子痫 胰岛素样生长因子-Ⅱ 血清 Preeclampsia Insulin-like growth factor-Ⅱ(IGF-Ⅱ) Serum
分类号 R714.24 [医药卫生—妇产科学]
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参考文献10

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  • 8Giuolice LC, Martina NA. Insulin - like growth factor binding protein -at the maternal - fetal interface and insulin - like growth factor - Ⅰ, insulin- like growth factor - Ⅱ, and insulin - like growth factor bindingprotein - 1 in the circulation of women with severe preeclampsia. Am J Obstet, 1997; 176; 751-758.
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中国妇幼保健
2005年 第8期

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