妊高征患者血清新喋呤、白介素2及可溶性受体的变化与意义

Changes of serum neopterin, Ill-2 and soluble IL-2 receptor in pregnancy-induced hypertension and its significance

目的:通过观察妊高征患者血清新喋呤、白介素2及可溶性受体(sIL-2R) 水平的变化, 探讨妊高征患者细胞免疫功能的变化及意义。方法: 采用酶联免疫吸附分析法与放射免疫分析法测定28例妊高征(轻、中度12例, 重度16例)和30例正常孕妇的血清新喋呤、白介素2和sIL-2R水平; 比较二组间新喋呤、白介素2和sIL-2R水平的差异; 观察新喋呤、白介素2和sIL-2R水平与妊高征病情的关系。结果: 妊高征患者血清新喋呤、白介素2和sIL-2R水平显著高于对照组(t'=4 543, P<0 .001; t=2. 946, P<0. 01; t'=2 .251, P<0. 05); 重度妊高征患者新喋呤水平显著高于轻、中度患者(t'=2 .913,P<0 .01), 重度妊高征患者与轻、中度患者组比较白介素2和sIL-2R均无显著性差异(t=0 .888, P>0 .2; t=0. 444, P>0 .5)。结论: 妊高征患者血清新喋呤、白介素2及可溶性受体水平显著增高, 新喋呤水平随妊高征病情加重而增高, 提示细胞免疫活性增强可能与妊高征的发生和发病有关。

Objective:By observing the changes of serum neopterin, IL-2 and soluble IL-2 receptor (sIL-2R) levels in pregnancy-induced hypertension (PIH) to explore cellular immune function in patients with PIH and its significance.Methods:Serum neopterin, IL-2 and sIL-2R levels in 28 patients with PIH (12 cases with mild and moderate PIH, 16 cases with severe PIH) and 30 normal controls were determined by ELISA and radioimmunity assay.Results:Serum neopterin, IL-2 and sIL-2R levels in patients with PIH were higher than those in controls ( t'=4.543, P<0.001; t'=2.946, P<0.01; t'=2.251, P <0.05); serum neopterin in patients with severe PIH were significantly higher than those in ones with mild and moderate PIH ( t'=2.913, P <0.01), there were no significant difference in serum IL-2 and sIL-2R among patients with PIH ( t=0.888, P>0.2; t=0.444, P >0.5). Conclusion:Serum neopterin, IL-2 and sIL-2R levels in patients with PIH significantly increased, neopterin levels increased with severity degree of PIH, which suggested that cellular immune activity enhancement might be related to pathogenesis of PIH.